4. Docetaxel interferes with the function of microtubules, resulting in inactive microtubule bundles, causing cells to die. Exercise can help combat fatigue; a simple daily walk with a friend can help. My kids are 10 and 5. Chemotherapy kills regular cells, as well as cancer cells, and this is why side effects occur . It really helped me that there was a gap between the two sets of chemo cycles, gave me a chance to recover a bit from the taxotere before starting the treatments again. Its normal to feel completely wiped out when you begin this medication. I have severe bloating which is so uncomfortable its almost painful. Taxotere is a part of many peoples cancer journey. 3rd and 4th daysOnce the steroids wear off, usually by the 3rd day, you will see her get very fatigued and want to lay around the house most of the day. How many treatments is she having? For some people, it never completely goes away. Try some meditation (use an app if you don't have any). Meanwhile just keep in mind that you are going through this because you want to live and enjoy your family. Some chemotherapy medications can cause neuropathy (numbness or tingling in your hands and feet). Need to get myself prepared for the next one. Knowing How to Handle Your Worst Days on Taxotere. I had the sore mouth too but I must have been one if the lucky ones as I do not remember too many other side effects - it was 7 years ago. When thered cell count is low, you may feel tired or weak. Taxotere was my aggressive chemo, and it caused the majority of the side effects the hair loss, nausea, all these different things. While it sounds harmless enough, constantly tearing eyes can cause other health issues. I am trying to keep focused and positive to get through this. I expected it to be tough but it has nearly broken me. I spent yesterday in A&E with chest pains which turned out to be heartburn and anxiety. Whole body ache , muscles and joints, headaches, kidney pains, swolen glands, lethargy and over emotion. Hopefully this will continue for the last 2 cycles. I would have Gemcitabine on week one. I'm hopeful tomorrow will be a better day. I need to focus on this and get back on track. Painkillers, she had all the same things as you. It takes the edge off the pain which means taking paracetamol with it actually works. Hello there, Two weeks to recover! Xx, Hi Berylynn, thank you for the support, we are certainly in this together for you are experiencing some of the same issues as me with this dreadful new chemo. Taxotere Chemo: April 29 2010 May 20 2010 June 10 2010 July 1 2010. Laughter is fast-acting, too. Your Wife is unique! Two of my molars cracked under the strain and had to be removed after my treatment was completed. Take care. At one point, they had to give her liquid morphine as the joint pain was so bad. Shower or bathe daily and perform frequent. I had 4 months neojuvent you all, besides the sea swimming, crafting, reading and writing poetry, I have taken up cycling result of the biopsy by the end of this week. Include fiber in your diet (fruits and vegetables), drink 8-10 glasses of non-alcoholic fluids a day, and keep active. I was diagnosed with grade 3 breast cancer in may. (I too read somewhere that grapefruit can make the side-effects of the drug worse). Really sorry to read that you having such a s---- time with your current chemo treatment. Avoid drinking alcohol on the day of your Taxotere injection. I end up with wet pillows at nightnever had that with Tamaxifen or in 50s. I am just unfortunate to get them all. Liked the clearer head but found days 3 to 6 the worst when ankles, knees or hips gave way. keep up the good work you have been doing and are still doing. In some ways was easier, in others was more taxing (pun intended)! If the platelet count becomes too low, you may receive a transfusion of platelets. Taxotere is one of many breast cancer chemotherapy drugs. Paracetamol not helping at all I could scream! So always stay in touch with the team.. Im out now on antibiotics.. I know how awful Chemo is and I have been lucky that I haven't too many bad side effects I have delt with them as I got them. The use of scarves, wigs, hats, and hairpieces may help. the feet problems still continues now and I have now lost all toenails and most fingernails - bu the important thing is that they looked great with fuschia Shellac for my wedding day and honeymoon! Brush with a soft-bristle toothbrush or cotton swab twice a day. The infusion will be slowed or stopped if this occurs. Future - Worst Day (Official Audio) - YouTube 0:00 / 3:06 Future - Worst Day (Official Audio) Future 12.5M subscribers Subscribe 2.5M views 1 year ago #Future #WorstDay Future - Worst. Each mL contains 40 mg docetaxel (anhydrous) and 1040 mg polysorbate 80. Researchers spent YEARS finding chemotherapy compounds that could attack prostate cancer cells. Eyes watery but ok. I have finished 4 cycles so far with 4 more to go. Any comments, please. Itis designed to target malignant cancer cells in your body. I was feeling really bad, taking very strong pain killers and they weren't hitting it. Week Three was Im actually feeling pretty good and then you go right back to Week One. I know that treats are not offically a cure but i try and put nice things in the bad days so not everything is about cancer . I wish I rang sooner. I have a good support system at home who do just about everything as I have been bed or sofa bound for the last 10 days with just small walks around the house to keep the circulation going. The problem some people run into with Taxotere is that the hair loss can sometimes be permanent. If we can get through this we can face anything. They get worse with each cycle. Hair generally starts to regrow soon after treatment is completed. White endeared himself to Jets fans over the last two years with his inspiring play as Zach Wilson's backup. Took 1 pill starting the day before chemo and for the next 4 days. Found the freeze gell hit the joint areas better and gave relief. You have given me some great pointers and hopefully I can be calmer about my next 2 cycles. Thanks everyone for your messages of support. I did not start feeling better until the 5 or 6th day after chemo. Men initially treated with Taxotere had favorable outcomes compared to those who were initially treated with Novantrone: Median overall survival was 22 months for men treated with Taxotere first and 15 months for those treated with Novantrone first. Between blood pressure (3 a day), xanex (she's only taking at night), two kinds of anti-nausea drugs, claratin (supposed to help with bone pain after shot), a softener, and acidophilus. White blood cells (WBC) are important for fighting infection. I've just had my first Docetaxel 5 days ago and boy am I sufferingshooting painsin lower back, kidney area,legs andshoulders for two days now. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Days 1,8: Gemcitabine 900mg/m 2 IV at a rate of 10mg/m 2 /minute, followed by: Day 8: Docetaxel 75-100mg/m 2 IV over 1 hour. I've been prescribed Gabapentin, spoke to my oncologist after the first docetaxel. My next 2 cycles went ok so, hopefully you are through the worst. Brady appears to be expanding his brand rapidly in 2023. Keep well. Leg pain also bad tonight, I am on day 5 after first Taxotere chemo so I suppose it's working at its height at the moment, hope it gets better in the coming days! I think I am coming to the end of feeling like I have hit by a bus with the chronic aches in all my joints and bones. neuropathy, or pain caused by nerve damage. With Taxotere, I have had bad stomach aches, back aches, extremely low energy, trouble tasting food, and minimized appetite. Fatigue. Common reported side effects of Taxotere (docetaxel) include: Injection site pain or swelling Temporary hair loss Nausea Vomiting Diarrhea Constipation Loss of appetite Fingernail or toenail changes Using unprocessed Doc and both nanoparticles, PRINT-Doc-80300 and PRINT-Doc-200200, Chu et al. Use seasonings like basil, oregano, or rosemary to add flavor. You should let your doctor or nurse know right away if you have a fever (temperature greater than 100.4F /38C), sore throat or cold, shortness of breath, cough, burning with urination, or a sore that doesn't heal. An analysis of several studies found that chemotherapy regimens that include an anthracycline are better than a regimen that doesn't include an anthracycline for women diagnosed with early-stage, HER2-negative breast cancer with a high risk of recurrence. TAXOTERE (docetaxel) Injection Concentrate is a clear yellow to brownish-yellow viscous solution. Taxotere is part of a family of drugs known as taxanes that work by preventing cell growth. Docetaxel is its generic name, and it belongs to the taxane class of drugs. Today it was announced that his name would be on a car at Le Mans. In the beginning the changes in taste and nausea started about day 4 and lasted about 1 week. Its common to lose hair when youre undergoing cancer treatments. The interval between each treatment gives your body time to recover. Last injection today. Use of this online service is subject to the disclaimer and the terms and conditions. It was just the drugs working their way through my system. Premedication is required with Docetaxel. X, Reading all the comments, many of us have been through the mill with this 4th treatment. Anemia, or a shortage of red blood cells, can make you very tired. Docetaxel can cause your body to hold too much fluid, which can be a serious side effect. Do not use a razor (an electric razor is fine). Keeping positive and looking forward to getting to the end of it all. xx, I too had terrible 1st cycle and likewise was admitted due to high temp feel better now but due next cycle on we'd feeling scared I have 3 very young children am incurable breast cancer not sure can cope am now on injection to keep blood count up, Sorry to hear of your experience Jazzy, I know it's not pleasant. I was 'tired' on days 3 & 4 on A/C but napping/resting helped. Make sure she is getting alot of water, eat fruits and vegetables. Patients on the TAXOTERE arm received TAXOTERE (T) 75 mg/m 2 by intravenous infusion on day 1 followed by cisplatin (P) 100 mg/m 2 administered as a 30-minute to three-hour intravenous infusion, followed by the continuous intravenous infusion of fluorouracil (F) 1000 mg/m 2 /day from day 1 to day 4. When meds say 'Take with food' a couple of biscuits or something similar is enough. I am sorry to read that the chemo is hitting you so hard.If there is a magic answer i never found it but the things that were usefull to me were -dont eat befor chemo and walk afterwards.If you can get your body going-even if it is to the end of the road and back and you feel like **** I found it seemed to get your system going at least a bit. This is usually mild to moderate and I find that most patients are able to continue many of their regular activities. By 2010, the drug had . For your mouth get som kingingical mouth wash and rinse with salt water every hour or so. Differences in clearance for the two PRINT particles suggest that shape plays a role in reducing clearance by the MPS and enhancing tumor delivery. Please. Worst days when i was on 3chemo meds, taxotere, carbon, and Herceptin, were 3-5 days after. Know that you are two thirds of the way there. In the larger STAMPEDE trial (2962 patients), adding docetaxel to standard hormonal therapy significantly improved survival among men with newly diagnosed, hormone-nave advanced prostate cancer. How Docetaxel Is Given: Docetaxel is given through a vein (intravenously, IV) There is no pill form of docetaxel ; Premedication with a corticosteroid pill starting a day prior to docetaxel infusion for 3 days is given to reduce the severity of fluid retention and allergic reactions. Sounds like you have had quite a week, similar to mine. Rough night last night; not sleeping well. TAXOTERE was first approved for the F.D.A. But by the sound of it a lot of you needed that third week to recover, she won't have that. It had to have been that I just did too much. Do not cut cuticles or ingrown nails. The most common side effect in day-to-day life is fatigue. I finished T & C on April 1 (total of 6 treatments). Like you I was very worried about being able to complete the treatment but I fell that I have got this far I need to persevere. For cycle 2 I used a great mouthwash - Difflam and have had no sore mouth problems since. Cyclophosphamide is a type of chemotherapy medicine . It is used as a treatment for various cancers, most notably breast cancer. I had my 2nd cycle of Docetaxel yesterday. Youre coming back off. The cycles were repeated every 3 weeks for 3 . I want to speak with the Oncologist about the strength of Docetxel used it it seems very high at 200mg. Make sure that those around you understand that while the pain peaks, you need absolute rest. Take care, week 3 coming up soon! It's now a week since my 1st cycle of Docetaxel following 3 cycles of FEC, it has been a dreadful week where the treatment has thrown back every side effect possible. Then yesterday; she was miserable all day; felt weak; and couldn't really describe the bad feeling in her body. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling . Discover information about different types of cancer, Learn about cancer, diagnosis, treatment, coping & survivorship, Find resources & tools for oncology healthcare professionals. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea. I hope your teeth are in good condition. I think it would have been better to know just what to expect but as we all react different it's not possible. While on cancer treatment, and for a period after, you may need to adjust your schedule to manage fatigue. I was severely feverish, my whole body ached to the point that I felt like I was in a can crushing machine, I felt sick and my mouth was worse than ever (it had been bad all the way through). It causes numbness or a tingling feeling in the hands and/or feet, often in the pattern of a stocking or glove. However, our monthly flat rate of just $49 per medication . Stay strong honey xxxxxxxxxxx, Thank you Lainey66, I will give Kin gingival a try as I feel I am in a vicious circle of mouth problems making eating difficult and tablets which need to be taken with food. constipation. In some people, the symptoms slowly resolve after the medication is stopped, but for some, it never goes away completely. Best wishes to everyone on this treatment and you will come out the other side. x. I had the same treatment last year and just as you I struggled with Fec but my first T absolutely knocked me side ways! I had my last taxen (chemo) two weeks ago and felt okay the first three days and then it hits. So far I have been ok on the 2nd cycle just starting to feel the side effects kicking in this evening . Hard to rest with all the side effects of all the drugs but I did my best. Will be glad to see you here soon Post Chemo, looking forward to your break away with your husband. an infection was never found, though. One of the most major Taxotere side effects is epiphora or, in simple terms, watery eyes. Then starting in June 2014, I had 15 doses of Radiotherapy. Take regular Paracetamol and Ibruprofen all day every day. I'll be starting this Thursday and have 10 steroids to take Wednesday night and then whatever they give me as pre-meds. With NiceRx you'll always pay a flat monthly fee of $49. Notify your oncology care team if your mouth, tongue, inside of your cheek or throat becomes white, ulcerated, or painful. Been told its best to as it helps the operation be morebsuccessful. I have been given so many tablets with this cycle which need to be taken with food but find eating almost impossible due to chemo mouth explosion of thrush despite being on medication. You may have some of the above symptoms or you may not. You should feel a lot better in about a week's time. Keep the thoughts positive. But by my third week I felt somewhat normal, would tire quick but normal. Nails still ok, feet and nails need constant cream sessions. We can get through it! So would recommend this. If mouth sores become painful, your doctor or nurse can recommend a pain reliever. If you notice any changes in how you feel during the infusion, let your nurse know immediately. worst: [adverb] to the extreme degree of badness or inferiority. After that, I have been okay - really tired and nothing tastes good so I am not eating well - but I learned from my first course of chemo that ended in April that I need to sleep when I am tired, so sometimes when I get home from work, I go right to sleep. I was informed that I would need a mastectomy as to the way the tumour is growing in the breast. I feel less guilty doing nothing for a fortnight if others the same sofa days do seem to be extended. I completed 4 doses of EC (1 every 3 weeks). Xx, Thanks Berylynn. I also lost all my taste buds. Days 4 and 5 were the hardest: nausea or just energy, emotions. So I feel that is a positive thought. I went back to work on Tuesday, but wasn't feeling the greatest. TAXOTERE safely and effectively. My husband has booked a cottage break in July to hopefully celebrate the end of chemo before my surgery. Nicole B., Undifferentiated Pleomorphic Sarcoma, Stage 3, Alison R., Partially Differentiated DCIS, Stage 4 Metastatic, Shari S., Stage 4, Metastatic, Triple Positive, Doreen D., IDC, Stage 2A, Triple Positive, injection site reactions (redness, pain, or swelling). Your physician will order lab tests throughout your treatment to keep an eye on your levels. Docetaxel can cause a dose-related reversible sensory neuropathy. On 9-1-09, I finished 6 cycles of Taxotere, Carboplatin and Herceptin. We have each other even if we don't know each other. I know what to expect now and feel better prepared for chemo cycle 5, 2nd of Docetaxel . The end is now in sight and just keep thinking what a good job the chemo is doing getting rid of this nasty disease. All patients should be premedicated with oral corticosteroids (see below for prostate cancer) such as dexamethasone 16 mg per day (e.g., 8 mg twice daily) for 3 days starting 1 day prior to TAXOTERE administration in order to reduce the incidence and severity of fluid retention as well as the severity of hypersensitivity reactions [see Boxed Warning, Warnings and . If it is hitting you hard hopefully the chemo will be kicking the cancer in the teeth. Taxotere is a chemotherapy drug that is used to treat various cancers such as breast cancer, non-small cell lung cancer, prostate cancer, gastroesophageal cancers, and head and neck cancers. Taxotere is a chemotherapy drug made by Sanofi-Aventis. I took Oestrogen suppressing tablets over July and August and restarted chem beginning of September with the FEC. It, like other chemotherapy medications, can have severe side effects. Even my vision has been effected. Most people notice that their neuropathy gets better 2 to 4 months after chemotherapy, but it can take up to 1 year to fully go away. I have previously been prescribed mouth wash, gel and drops to no avail this time round. Taxotere injections can cause serious and life-threatening fluid retention(edema). Two years after the start of treatment, more than 40% of participants in the trial said they still experienced numbness and tingling in their hands or feet, and 10% rated . If you feel unwell or have any of these signs, tell them straight away. All that said, she was down for a mastectomy too, except, the docetaxel absolutely obliterated the cancer. xx. You may wear nail polish, but not fake nails. The effects of chemo are cumulative. The taste improved just before the next treatment. 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