documents in the last year, by the Federal Highway Administration Wheat grain yield as affected by plant growth regulator in 2013, Wheat grain yield as affected by plant growth regulator in 2014. In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. The treatments were two nitrogen fertilization doses (60 and 20 kg ha-1), three wheat cultivars (BRS 208, BRS 220, and BRS . offers a preview of documents scheduled to appear in the next day's Finally, EPA has concluded that trinexapac-ethyl is not expected to pose a cancer risk, given the lack of evidence of carcinogenicity in the database. There was no lodging for any site or treatment in 2014. documents in the last year, 522 Bell. Wear suitable protective clothing. The analysis and recommendations made in this blog post are preliminary and based on research findings from 2013. For more information on the general principles EPA uses in risk characterization and a complete description of the risk assessment process, see http://www.epa.gov/pesticides/factsheets/riskassess.htm. Manganese and trinexapac-ethyl are compatible and seem to yield higher turf growth suppression than trinexapac-ethyl and iron. Products in this class include flurprimidol, paclobutrazol, ethephon and trinexapac-ethyl. We rated plots for lodging at harvest using a 1 10 scale with 0 equaling no lodging and 10 equaling complete lodging. This document has been published in the Federal Register. 1503 & 1507. Call a poison control center or doctor for treatment advice If in eyes Hold eye open and rinse slowly and gently with water for 15-20 minutes. Full disclosure: Syngenta donated the product for this trial, but the only funding for the research was provided by the Oklahoma Agricultural Experiment Station and the Oklahoma Cooperative Extension Service. Information about this document as published in the Federal Register. An endpoint of concern was not identified for the general U.S. population; however, the acute dietary assessment is protective of women that may become pregnant. I have served as an Assistant Professor and Small Grains Extension Specialist at Oklahoma State University since August 2019. Application of Palisade or Palisade plus Tilt increased grain yield at Perkins in 2014 even though there was no lodging. Trinexapac-ethyl is used to control the growth on various grass species and crops. 804(2). In addition to lowering the carrier volume which will lower the number of tanks needed for application in a given area boomless nozzles are a great way to quickly apply product throughout the golf course. has no substantive legal effect. Refer for medical attention . This citizen's comment appears to be directed at the underlying statute and not EPA's implementation of it; the citizen has made no contention that EPA has acted in violation of the statutory framework. Can you pronounce this word better Classification Codes. Trinexapac-Ethyl Influences Bispyribac-Sodium Absorption and Efficacy for Annual Bluegrass ( Poa annua) Control in Creeping Bentgrass ( Agrostis stolonifera) Published online by Cambridge University Press: 20 January 2017 Patrick E. McCullough and Stephen E. Hart Article Metrics Save PDF Share Cite Rights & Permissions Abstract This prototype edition of the The extract was directly injected into the HPLC system. of the issuing agency. The documents posted on this site are XML renditions of published Federal In the rat reproduction study, reproductive toxicity was not observed, but decreased pup survival and decreased pup body weight/body-weight gain during lactation were observed above the limit dose with only reduced body weight and food consumption observed in the parental animals (>1,200 mg/kg/day). Pesticide manufacturing (NAICS code 32532). Therefore, an additional 10x database UF was not retained for lack of inhalation toxicity data and these data are not being required. Average mass 252.263 Da. Consider lowering your first application rates. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. corresponding official PDF file on govinfo.gov. EPA has sufficient data to assess the hazards of and to make a determination on aggregate exposure for Trinexapac-ethyl including exposure resulting from the tolerances established by this action. Acute dietary risks are below the Agency's level of concern: 2.5% of the acute population adjusted dose (aPAD) for females 13 to 49 years old, the population group of concern. In laboratory experiments with annual . That notice referenced a summary of the petitions prepared by Syngenta Crop Protection, Inc., the registrant, which is available in the docket, http://www.regulations.gov. Unfortunately, iron and calcium harden water, which may reduce trinexapac-ethyl uptake into the leaf and lower growth suppression. Mix in manganese. documents in the last year, 983 Solubility in water, g/100ml at 20C: 0.28-2.11 (pH-dependent). This feature is not available for this document. Consistent with section 408(b)(2)(D) of FFDCA, and the factors specified in section 408(b)(2)(D) of FFDCA, EPA has reviewed the available scientific data and other relevant information in support of this action. Until the ACFR grants it official status, the XML The Office of Management and Budget (OMB) has exempted these types of actions from review under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). This site displays a prototype of a Web 2.0 version of the daily ChemSpider ID 83439. documents in the last year, 11 My program focuses on developing science-based information to improve the agronomic and economic viability of small grains production in Oklahoma and in the Southern Great Plains. Superintendents across the Southeast are looking for ways to maintain their golf course with fewer staff members. are not part of the published document itself. Based on the lack of evidence of carcinogenicity in two adequate rodent carcinogenicity studies, trinexapac-ethyl is not expected to pose a cancer risk to humans. The Public Inspection page may also The North American Industrial Classification System (NAICS) codes have been provided to assist you and others in determining whether this action might apply to certain entities. The President of the United States manages the operations of the Executive branch of Government through Executive orders. Chronic oral toxicity studydog. by the Patent and Trademark Office Under FFDCA section 408(g), 21 U.S.C. Any trinexapac-ethyl that hits the soil is lost. Specific information on the studies received and the nature of the adverse effects caused by trinexapac-ethyl as well as the no-observed-adverse-effect-level and the lowest-observed-adverse-effect-level from the toxicity studies can be found at http://www.regulations.gov in the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed p. 48 in docket ID number EPA-HQ-OPP-2010-0524. You must file your objection or request a hearing on this regulation in accordance with the instructions provided in 40 CFR part 178. Liquid formulations containing organic solvents may be flammable. EPA has determined that reliable data show the safety of infants and children would be adequately protected if the FQPA SF Start Printed Page 12744were reduced to 1. Federal Register. EPA has established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2010-0524. Trinexapac-ethyl is classified as "Not likely to be carcinogenic to humans." The combined chronic toxicity/carcinogenicity study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans. Chastain, M.P. Trinexapac-Ethyl C13H16O5 at Best Price in Mumbai, Maharashtra | National Analytical Corporation - Chemical Division 100 Onwards INR Get Latest Price Minimum Order Quantity : 1 Kilograms/Kilograms Molecular Weight 252.26 Grams (g) Molecular Formula C13H16O5 View more details Accepts all Domestic/Foreign inquiries Send Inquiry Quick Resources. Many Oklahoma wheat farmers battled lodged wheat in 2013 and are looking to plant growth regulators to help reduce lodging in 2014. 1. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Federal Register. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. Trinexapac-ethyl | C13H16O5 - PubChem Apologies, we are having some trouble retrieving data from our servers. To ensure proper receipt by EPA, you must identify docket ID number EPA-HQ-OPP-2020-0046 in the subject line on the first page of your submission. Trinexapac-ethyl. The lesions remained confined to the supporting cells in the central nervous system and did not progress to more advanced or more extensive damage of the nervous tissue. 3. Further information about EPA's risk assessment and determination of safety can be found at http://www.regulations.gov in the document titled Trinexapac-ethyl. Short- and intermediate-term risk. ).However, the seed yield responses of annual ryegrass (Lolium multiflorum Lam.) Publicly available docket materials are available in the electronic docket at http://www.regulations.gov, or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. 0 ii. 02/28/2023, 205 When low carrier volumes are coupled with finer spray particles, it seems that lower product rates can be used because foliar coverage is maximized. on NARA's archives.gov. This repetition of headings to form internal navigation links Trinexapac-ethyl effects on red clover seed crops . Chemical Name: Trinexapac-ethyl: Section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizes EPA to allow an unregistered use of a pesticide for a limited time if EPA determines that an emergency condition exists. In this section you will find the primary documents produced to support the registration and review processes. All rights reserved. documents in the last year, 861 Using the exposure assumptions described in this unit for chronic exposure, EPA has concluded that chronic exposure to trinexapac-ethyl from food and water will utilize 6% of the cPAD for children 1 to 2 years old, the population group receiving the greatest exposure. Chemical Review Manager: Kelly Ballard (ballard.kelly@epa.gov), 703-305-8126. This final rule does not contain any information collections subject to OMB approval under the Paperwork Reduction Act (PRA), 44 U.S.C. Lodging as affected by plant growth regulator in 2013. ), nor does it require any special considerations under Executive Order 12898, entitled Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (59 FR 7629, February 16, 1994). (We`ll never share your email address with a third-party.). We conducteda separate trial evaluating Palisade in drought stress environments that was partially funded by Syngenta. Mohammad Hossein Sheikh Mohammadi, et al. We conducted the trial at Stillwater (Irr), Perkins (Irr), and Chickasha (Non-Irr). Inquiry Basket () February,13th,2023; Hebei Luantong trade.co China Manufacturer with main products:bmk ,Organic intermediate ,Food additive. A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20C; on spraying or dispersing, however, much faster. Only official editions of the the official SGML-based PDF version on govinfo.gov, those relying on it for // --> Lodging occurs due to a variety of factors, and as shown in the figure below, the timing of lodging will determine the final impact on grain yield. Be sure to consider the method of trinexapac-ethyl application when trying to maximize effectiveness. Recommendations may change as further research is conducted and new information is obtained. Please review additional information about the docket available at http://www.epa.gov/dockets. . However, to the best of our knowledge, TE has not been used to study the requirement of GAs in onset of germination. Open for Comment, Economic Sanctions & Foreign Assets Control, Electric Vehicle Standards and Requirements, Further Advancing Racial Equity and Support for Underserved Communities Through the Federal Government. 02/28/2023, 239 No. 4. EPA has sufficient data to assess the hazards of and to make a determination on aggregate exposure for trinexapac-ethyl including exposure resulting from the tolerances established by this action. 601 et seq.) The Agency used screening level water exposure models in the dietary exposure analysis and risk assessment for trinexapac-ethyl in drinking water. The product may cause mild eye irritation. Gibberellin is a plant hormone that promotes growth of various plant organs. documents in the last year, 287 Due to public health concerns related to COVID-19, the EPA Docket Center and Public Reading Room are closed for the time being, although EPA staff are continuing to provide remote assistance. No lodging occurred in 2014 regardless of treatment. documents in the last year, 822 Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a tolerance (the legal limit for a pesticide chemical residue in or on a food) only if EPA Start Printed Page 70063determines that the tolerance is safe. Section 408(b)(2)(A)(ii) of FFDCA defines safe to mean that there is a reasonable certainty that no harm will result from aggregate exposure to the pesticide chemical residue, including all anticipated dietary exposures and all other exposures for which there is reliable information. This includes exposure through drinking water and in residential settings, but does not include occupational exposure. Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. that agencies use to create their documents. Monoisotopic mass 252.099777 Da. Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. 2012-4984 Filed 3-1-12; 8:45 am], updated on 4:15 PM on Tuesday, February 28, 2023, updated on 8:45 AM on Tuesday, February 28, 2023, 104 documents 2023 United States Golf Association. %PDF-1.6 % Based upon review of the data supporting the petition, EPA has revised most of the proposed tolerance levels, added tolerances for hog fat and meat, and deleted the proposed tolerance for cattle kidney. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. Employees. Please note that, to comply with Canada's . =;Xb`0[,o DUv These can be useful establishing the XML-based Federal Register as an ACFR-sanctioned The suppliers of 39 Trinexapac-ethyl on the search result are been verified by the accurate information of each one. endstream endobj 1017 0 obj <>/Metadata 25 0 R/Pages 1014 0 R/StructTreeRoot 31 0 R/Type/Catalog>> endobj 1018 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 1019 0 obj <>stream This regulation establishes tolerances for residues of trinexapac-ethyl in or on multiple commodities which are identified and discussed later in this document. As to residue levels in food, EPA assumed that residues are present in all commodities at the tolerance level and that 100% of commodities with tolerances are treated with trinexapac-ethyl. Trinexapac-ethyl Chemical Structures GB RN 1422 Trade Name LPI.A004 Label Indication Conventional Chemical CB RN 756428 Country USA Company LOVELAND PRODUCTS, INC. CAS RN 143294-89-7; 104273-73-6 Product Type Formulation IUPAC Name 4- [cyclopropyl (hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid Compound Indication The chemical structure of trinexapac-ethyl, including the . documents in the last year, 20 Carefully collect remainder. In this Issue, Documents documents in the last year. This MRL is different than the tolerances established for trinexapac-ethyl in the United States. Section 408(b)(2)(D)(v) of FFDCA requires that, when considering whether to establish, modify, or revoke a tolerance, the Agency consider available information concerning the cumulative effects of a particular pesticide's residues and other substances that have a common mechanism of toxicity. EPA has not found trinexapac-ethyl to share a common mechanism of toxicity with any other substances, and trinexapac-ethyl does not appear to produce a toxic metabolite produced by other substances. publication in the future. Under FFDCA section 408(g), 21 U.S.C. Process Trigger: First Food Use Registration Review Case: TRINEXAPAC-ETHYL , Case #7228: Substance Information . Trinexapac-ethyl is a plant growth regulator that inhibits the formation of gibberellic acid and is used as an anti-lodging agent. Federal Register provide legal notice to the public and judicial notice Fresh air, rest. DER - Trinexapac-ethyl in Water - MRIDs 49282805 & 49282806 (pdf) (238.77 KB) Contact Us to ask a question, provide feedback, or report a problem. Based on the residential use patterns for trinexapac-ethyl, chronic residential exposure to residues is not expected. The method may be requested from: Chief, Analytical Chemistry Branch, Environmental Science Center, 701 Mapes Rd., Ft. Meade, MD 20755-5350; telephone number: (410) 305-2905; email address: residuemethods@epa.gov. documents in the last year, 121 4-(cyclopropyl-hydroxy methylene)-3,5-dioxo- cyclohexanecarboxylic acid ethyl ester 4-(cyclopropyl-hydroxy-methylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl esterTrinexapac-ethylethyl (RS)-4-cyclopropyl(hydroxy)methylene-3,5-dioxocyclohexanecarboxylateethyl 4-cyclopropyl(hydroxy)methylene-3,5-dioxocyclohexanecarboxylate, Moddus;ethyl 4-[cyclopropyl(hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylate;Trinexapac-ethyl. Prenatal and postnatal sensitivity. Combustible. Seed weight was generally inversely related to yield; trinexapac-ethyl treatments that produced the highest yield also had the lowest seed weight. Roanoke, VA 24016. Compliance with the tolerance levels specified below is to be determined by measuring both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and the associated metabolite, trinexpac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. The article can be found at the link below: Anderson, N.P., D.P. In evaluating dietary exposure to trinexapac-ethyl, EPA considered exposure under the petitioned-for tolerances. How can I get electronic access to other related information? Bethany Benbow, Registration Division (7505P), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave. Keep the chemical in suitable and closed containers for disposal. EPA has evaluated the available toxicity data and considered its validity, completeness, and reliability as well as the relationship of the results of the studies to human risk. documents in the last year, 37 Trinexapac-ethyl is classified as Not likely to be carcinogenic to humans. The combined chronic toxicity/carcinogenicity study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans. Petition 0F7719 requested that 40 CFR part 180 be amended by establishing tolerances for residues of the plant growth regulator, trinexapac-ethyl and its primary metabolite CGA-179500, in or on grass, forage, grown for seed at 1.60 parts per million (ppm); grass, hay, grown for seed at 3.5 ppm; grass, seed screenings, grown for seed at 45.0 ppm; grass, straw, grown for seed at 12 ppm; cattle (fat, meat, meat byproducts) at 0.05 ppm; goat (fat, meat, meat byproducts) at 0.05 ppm; horse (fat, meat, meat byproducts) at 0.05 ppm and sheep (fat, meat, meat byproducts) at 0.05 ppm. Also, the Agency calculated dietary burden differently by using the highest residue measured in trials instead of the proposed tolerance level residues. Sign in to access your AXS Fan Account to manage your tickets. Adequate enforcement methodology (Method GRM020.01A, which utilizes high performance liquid chromatography with triple-quadrupole mass spectrometry (LC-MS/MS)) is available to enforce the tolerance expression. These markup elements allow the user to see how the document follows the Lodging at head emergence, for example, can cause as little as 30 or as much as 80% yield reduction. This action is not a major rule as defined by 5 U.S.C. C. How can I file an objection or hearing request? In the mouse, there was no evidence of carcinogenicity. In general. Product Name: Trinexapac-ethyl: CAS No. with the Chemical Abstracts Service number 95266-40-3. Golf faces challenges and opportunities that are vital to its long-term health. Export Percentage. on FederalRegister.gov Residues were extracted from wheat with acetonitrile in aqueous phosphate buffer (pH 7) overnight. Trinexapac-ethyl Chemical Structures GB RN 1422 Trade Name GOVERNOR G Label Indication Conventional Chemical CB RN 748461 Country USA Company THE ANDERSONS, INC. CAS RN 143294-89-7; 104273-73-6 Product Type Formulation IUPAC Name 4- [cyclopropyl (hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid Compound Indication PLANT GROWTH REGULATOR The acute dietary exposure was only estimated for females 13 to 49 years old based on an in utero effect (decrease in mean number of fetuses/litter and an increase in post-implantation loss) identified in the rabbit developmental study. Schedule for Beginning Reviews. How can I get electronic access to other related information? Emergency exemptions may be requested by a state or federal agency. Table 1Summary of Toxicological Doses and Endpoints for Trinexapac-ethyl for Use in Human Health Risk Assessment. Remove all sources of ignition. better and aid in comparing the online edition to the print edition. Recommendations may change as further research is conducted and new information is obtained. 2. headings within the legal text of Federal Register documents. Cancer. from 47 agencies. 4. Open for Comment, Economic Sanctions & Foreign Assets Control, Electric Vehicle Standards and Requirements, Further Advancing Racial Equity and Support for Underserved Communities Through the Federal Government, Addendum to the Human Health Risk Assessment for Trinexapac-ethyl, Revised Residue Chemistry Chapter for Triexapac-ethyl. 02/28/2023, 43 Trinexapac-ethyl. This action does not involve any technical standards that would require Agency consideration of voluntary consensus standards pursuant to section 12(d) of the National Technology Transfer and Advancement Act of 1995 (NTTAA), Public Law 104-113, section 12(d) (15 U.S.C. Establish reliable relationship between buyers and suppliers through our matching services and find new business opportunities through various online exhibitions. This additional margin of safety is commonly referred to as the FQPA SF. 5. 02/28/2023, 828 MODDUS contains trinexapac-ethyl for use as a growth regulator in wheat, barley, oats, rye, triticale, durum wheat and ryegrass seed crops. Acute risk. documents in the last year, 1479 Syngenta Crop Protection, Inc. requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). provide legal notice to the public or judicial notice to the courts. In the Federal Register of March 3, 2020 (85 FR 12454) (FRL-10005-58), EPA issued a document pursuant to FFDCA section 408(d)(3), 21 U.S.C. on include documents scheduled for later issues, at the request To maximize effectiveness in residential settings, but does not contain any information subject... How can I file an objection or hearing request request a hearing this. Incineration with flue GAs scrubbing is possible for combustible packaging materials complete.! C. how can I get electronic access to other related information seem yield. Combined chronic toxicity/carcinogenicity study in the last year, 20 Carefully collect remainder find the primary produced... In accordance with the instructions provided in 40 CFR part 178 had the lowest seed weight was generally inversely to. Plenty of water for several minutes ( remove contact lenses if easily ). Responses of annual ryegrass ( Lolium multiflorum Lam. ) article can be found at http: //www.regulations.gov in document. With Canada & # x27 ; s Perkins in 2014 even though there no. Through drinking water and in residential settings, but does not contain any information collections subject to approval., 37 trinexapac-ethyl is a plant hormone that promotes growth of various plant organs to plant growth regulator inhibits. ( PRA ), Perkins ( Irr ), 21 U.S.C ( ID ) number.! Seed by storage or disposal is possible for combustible packaging materials provide legal notice to the of. Yield at Perkins in 2014 even though there was no evidence of carcinogenicity is different than tolerances..., the seed yield responses of annual ryegrass ( Lolium multiflorum Lam. ) method... Minutes ( remove contact lenses if easily possible ), 703-305-8126 in evaluating dietary exposure analysis risk. Public or judicial notice Fresh air, rest third-party. ) titled trinexapac-ethyl chronic residential exposure to trinexapac-ethyl which! Plant hormone that promotes growth of various plant organs is sold under the petitioned-for tolerances settings, but does include! Regulator in 2013 and are looking to plant growth regulator in 2013 and 2014 we evaluated plant. Basket ( ) February,13th,2023 ; Hebei Luantong trade.co China Manufacturer with main products: bmk, Organic intermediate, additive. Products in this section you will find the primary documents produced to support registration. Of GAs in onset of germination ryegrass ( Lolium multiflorum Lam. ) treatments that produced highest! Requested by a State or Federal Agency the plant growth regulators to help reduce lodging in 2014 on! This includes exposure through drinking water and in residential settings, but does not include occupational exposure turf growth than. Ryegrass ( Lolium multiflorum Lam. ) C13H16O5 - PubChem Apologies, we are having some trouble data... And determination of safety can be found at http: //www.epa.gov/dockets to yield higher turf growth suppression trinexapac-ethyl. By Syngenta classified as not likely to be carcinogenic to humans Substance information additive... The residential Use patterns for trinexapac-ethyl in drinking water therefore, an additional 10x UF... Used screening level water exposure models in the last year, 37 trinexapac-ethyl is a plant growth regulators to reduce. Http: //www.regulations.gov in the Federal Register repetition of headings to form internal navigation links trinexapac-ethyl on! 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Were extracted from wheat with acetonitrile in aqueous phosphate buffer ( pH 7 ) overnight generally... Establish reliable relationship between buyers and suppliers through our matching services and find new opportunities. China Manufacturer with main products: bmk, Organic intermediate, Food additive be to... Of Toxicological Doses and Endpoints for trinexapac-ethyl, EPA considered exposure under the Paperwork Reduction Act ( ).